It is the last version of Microsoft Office to support Windows 7 SP1, Windows Server 2008 R2 SP1, Windows 8, Windows Server 2012, Windows 8.1, Windows Server 2012 R2, Windows 10 RTM–1803 and Windows Server 2016 as the following version, Microsoft Office 2019 only supports Windows 10 version 1809, Windows Server 2019 or later. Office 2016 requires Windows 7 SP1, Windows Server 2008 R2 SP1 or OS X Yosemite at the minimum. The perpetually licensed version on macOS and Windows was released on September 22, 2015. Mainstream support ended on October 13, 2020, and extended support for most editions of Office 2016 will end on October 14, 2025, the same day as Windows 10.

It was released on macOS on July 9, 2015, and on Microsoft Windows on September 22, 2015, for Office 365 subscribers. Microsoft Office 2016 (First perpetual release of Office 16) is a version of the Microsoft Office productivity suite, succeeding both Office 2013 and Office for Mac 2011 and preceding Office 2019, which in turn was succeeded by Office 2021 for both platforms. Proofing only (11): Hausa, Igbo, isiXhosa, isiZulu, Kinyarwanda, Pashto, Romansh, Sesotho sa Leboa, Setswana, Wolof, YorubaĮnglish, Arabic, Chinese (Simplified), Chinese (Traditional), Czech, Danish, Dutch, Finnish, French, German, Greek, Hebrew, Hungarian, Indonesian, Italian, Japanese, Korean, Norwegian (Bokmål), Polish, Portuguese (Portugal), Portuguese (Brazil), Russian, Slovak, Spanish, Swedish, Thai, Turkish.Partial (51): Afrikaans, Albanian, Amharic, Armenian, Assamese, Azerbaijani (Latin), Bangla (Bangladesh), Bangla (Bengali India), Basque (Basque), Belarusian, Bosnian (Latin), Catalan, Dari, Filipino, Galician, Georgian, Gujarati, Icelandic, Irish, Kannada, Khmer, KiSwahili, Konkani, Kyrgyz, Luxembourgish, Macedonian (FYROM Macedonia), Malayalam, Maltese, Maori, Marathi, Mongolian (Cyrillic), Nepali, Norwegian Nynorsk, Odia, Persian (Farsi), Punjabi (Gurmukhi), Quechua, Scottish Gaelic, Serbian (Cyrillic, Bosnia & Herzegovina), Serbian (Cyrillic, Serbia), Sindhi (Arabic), Sinhala, Tamil, Tatar (Cyrillic), Telugu, Turkmen (Latin), Urdu, Uyghur, Uzbek (Latin), Valencian, Welsh.

Full (40): Arabic, Bulgarian, Chinese (Simplified), Chinese (Traditional), Croatian, Czech, Danish, Dutch, English, Estonian, Finnish, French, German, Greek, Hebrew, Hindi, Hungarian, Indonesian, Italian, Japanese, Kazakh, Korean, Latvian, Lithuanian, Malay (Latin), Norwegian Bokmål, Polish, Portuguese (Brazil), Portuguese (Portugal), Romanian, Russian, Serbian (Latin, Serbia), Slovak, Slovenian, Spanish, Swedish, Thai, Turkish, Ukrainian, Vietnamese.

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